Was the one I cloned the drive in my Mini with. It would randomly disconnect from my system. It was one of the oldest ones I had and the rate at which these things have been dying off lately I should have almost expected it.
Replaced both the data cable and the power brick and it finally just seems to have stopped spinning the platter(s). Got newer ones I can use but fark! Makes my ass hurt.
Just makes that dreaded clicky - skritch - scratch noise that they all seem to make right before they croak.
And the dang mouse I use is looking like it is going to break down on me too. Been using it for gaming lately (and everything else too) so I guess I shouldn't really be surprised.